PedsQL Cognitive Functioning Scale in youth with epilepsy: Reliability and validity.
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OBJECTIVE: The objective of the study was to report on the internal consistency reliability and discriminant, concurrent and construct validity of the Pediatric Quality of Life Inventory (PedsQL) Cognitive Functioning Scale as a brief generic cognitive functioning measure in youth with epilepsy. METHODS: The 6-item PedsQL Cognitive Functioning Scale and 23-item PedsQL 4.0 Generic Core Scales were completed by 221 pediatric patients ages 5-18years with epilepsy and 336 parents of patients ages 2-18years in a national field test study for the PedsQL Epilepsy Module. Parents also completed the 86-item Behavior Rating Inventory of Executive Function (BRIEF), a widely validated measure of executive functioning. RESULTS: The PedsQL Cognitive Functioning Scale evidenced excellent reliability (patient self-report =0.88; parent proxy-report =0.96), distinguished between youth with epilepsy and an age, gender, and race/ethnicity-matched healthy sample supporting discriminant validity with large effect sizes (~20-30 point score differences, P<0.001), and demonstrated concurrent and construct validity, respectively, through large effect size intercorrelations with the BRIEF (Behavioral Regulation Index, Metacognition Index, Global Executive Composite Summary Scores rs=0.43-0.67, P<0.001) and the PedsQL Generic Core Scales (Total Scale Scores rs=0.67-0.74, P<0.001). Minimal clinically important difference (MCID) scores ranged from 5.92 to 8.80. CONCLUSIONS: The PedsQL Cognitive Functioning Scale demonstrated excellent internal consistency reliability, discriminant, concurrent, and construct validity in youth with epilepsy and may be suitable as a brief generic patient-reported outcome (PRO) measure for clinical research, clinical trials, and routine clinical practice in pediatric epilepsy.
