Neuroendocrine, autocrine, and paracrine control of follicle-stimulating hormone secretion. Academic Article

abstract

• Follicle-stimulating hormone (FSH) is a glycoprotein hormone produced by gonadotropes in the anterior pituitary that plays a central role in controlling ovarian folliculogenesis and steroidogenesis in females. Moreover, recent studies strongly suggest that FSH exerts extragonadal actions, particularly regulating bone mass and adiposity. Despite its crucial role, the mechanisms regulating FSH secretion are not completely understood. It is evident that hypothalamic, ovarian, and pituitary factors are involved in the neuroendocrine, paracrine, and autocrine regulation of FSH production. Large animal models, such as the female sheep, represent valuable research models to investigate specific aspects of FSH secretory processes. This review: (i) summarizes the role of FSH controlling reproduction and other biological processes; (ii) discusses the hypothalamic, gonadal, and pituitary regulation of FSH secretion; (iii) considers the biological relevance of the different FSH isoforms; and (iv) summarizes the distinct patterns of FSH secretion under different physiological conditions.

authors

• Cardoso, Rodolfo

published proceedings

• Mol Cell Endocrinol

altmetric score

• 3

author list (cited authors)

• Padmanabhan, V., & Cardoso, R. C.

citation count

• 12

complete list of authors

• Padmanabhan, Vasantha||Cardoso, Rodolfo C

publication date

• January 2020

publisher

• Elsevier  Publisher

published in

• Molecular and Cellular Endocrinology  Journal

keywords

• Animals
• Autocrine Communication
• Female
• Follicle Stimulating Hormone
• Humans
• Hypothalamus
• Ovary
• Paracrine Communication
• Pituitary Gland
• Reproduction

Digital Object Identifier (DOI)

• 10.1016/j.mce.2019.110632

start page

• 110632

end page

• 110632

volume

• 500

URL

• http://dx.doi.org/10.1016/j.mce.2019.110632