Sweet rescue or surrender of the failing heart? Academic Article

abstract

• Natriuretic peptides (NPs) are hormones involved in maintaining heart health that undergo proteolytic cleavage to become activated. Previous work has shown that O-GalNAc glycans affect their processing and activation. Here, Goetze, Schjoldager, and colleagues now provide comprehensive characterization of O-glycosylation of NPs, revealing that all members of the NP family can be modified by O-GalNAc glycans. Intriguingly, the study discovers glycans in the receptor-binding region of the A-type natriuretic peptide (ANP), demonstrating that they affect both stability and activity of ANP. These results may inform future therapeutic approaches for heart failure using peptide glycoforms.

authors

• Panin, Vladislav

published proceedings

• J Biol Chem

altmetric score

• 1.75

author list (cited authors)

• Chandel, I., Ten Hagen, K. G., & Panin, V.

citation count

• 0

complete list of authors

• Chandel, Ishita||Ten Hagen, Kelly G||Panin, Vlad

publication date

• August 2019

publisher

• Elsevier  Publisher

keywords

• Animals
• Glycosylation
• Heart Failure
• Humans
• Natriuretic Peptides
• Polysaccharides

PubMed Central ID

• 31444307

Digital Object Identifier (DOI)

• 10.1074/jbc.H119.010228

start page

• 12579

end page

• 12580

volume

• 294

issue

• 34

URL

• http://dx.doi.org/10.1074/jbc.h119.010228