Cuprous binding promotes interaction of copper transport protein hCTR1 with cell membranes. Academic Article uri icon


  • Cu(i) binds to the N-terminal metal binding domain (MBD) of hCTR1 and induces its conformational change, which promotes the interaction of the MBD with cell membranes. The membrane interaction was confirmed in living cells. This process could be the first step to initiate the cellular uptake of copper ions by hCTR1.

published proceedings

  • Chem Commun (Camb)

altmetric score

  • 0.25

author list (cited authors)

  • Yang, Y., Zhu, Y., Hu, H., Cheng, L., Liu, M., Ma, G., ... Liu, Y.

citation count

  • 8

complete list of authors

  • Yang, Yang||Zhu, Yang||Hu, Hongze||Cheng, Lanjun||Liu, Manman||Ma, Guolin||Yuan, Siming||Cui, Peixin||Liu, Yangzhong

publication date

  • September 2019