The REGγ-Proteasome Regulates Spermatogenesis Partially by P53-PLZF Signaling Academic Article uri icon

abstract

  • Development of spermatogonia and spermatocytes are the critical steps of spermatogenesis, impacting on male fertility. Investigation of the related regulators benefits the understanding of male reproduction. The proteasome system has been reported to regulate spermatogenesis, but the mechanisms and key contributing factors invivo are poorly explored. Here we found that ablation of REG, a proteasome activator, resulted in male subfertility. Analysis of the mouse testes after birth showed there was a decreased number of PLZF+ spermatogonia and spermatocytes. Molecular analysis found that REG loss significantly increased the abundance of p53 protein in the testis, and directly repressed PLZF transcription in cell lines. Of note, allelic p53 haplodeficiency partially rescued the defects in spermatogenesis observed in REG-deficient mice. In summary, our results identify REG-p53-PLZF to be a critical pathway that regulates spermatogenesis and establishes a new molecular link between the proteasome system and male reproduction.

published proceedings

  • Stem Cell Reports

altmetric score

  • 0.25

author list (cited authors)

  • Gao, X., Chen, H., Liu, J., Shen, S., Wang, Q., Clement, T. M., ... Li, L.

citation count

  • 12

complete list of authors

  • Gao, Xiao||Chen, Hui||Liu, Jian||Shen, Shihui||Wang, Qingwei||Clement, Tracy M||Deskin, Brian J||Chen, Caiyu||Zhao, Dengpan||Wang, Lu||Guo, Linjie||Ma, Xueqing||Zhang, Bianhong||Xu, Yunfei||Li, Xiaotao||Li, Lei

publication date

  • January 2019