The implications of sensitization and kindling for chronic fatigue syndrome Chapter uri icon


  • Many patients with chronic fatigue syndrome (CFS) have widespread pain which has a large role in patients' activity limitations. Central sensitization has been posited as an explanation of this pain in both Fibromyalgia (FM) and CFS. Repeated or sustained noxious stimulation can lead to central sensitization, which can cause the spinal cord to enter a "hyperexcitable" state. In this article, we will explore the relevance of the central sensitization theory for CFS, as well as link it to the kindling hypothesis that has been previously offered as one explanation for the etiology of CFS. The article also reviews the implications of this theory for both inflammatory markers and central nervous system involvement. © 2013 by Nova Science Publishers, Inc. All rights reserved.

author list (cited authors)

  • Jason, L. A., Sorenson, M., Evans, M., Brown, A., Flores, S., Sunnquist, M., & Schafer, C

complete list of authors

  • Jason, LA||Sorenson, M||Evans, M||Brown, A||Flores, S||Sunnquist, M||Schafer, C

Book Title

  • Encephalitis, Encephalomyelitis and Encephalopathies: Symptoms, Causes and Potential Complications

publication date

  • January 2013