Orchestration of Processing Body Dynamics and mRNA Decay in Arabidopsis Immunity Academic Article uri icon

abstract

  • Proper transcriptome reprogramming is critical for hosts to launch an effective defense response upon pathogen attack. How immune-related genes are regulated at the posttranscriptional level remains elusive. We demonstrate here that P-bodies, the non-membranous cytoplasmic ribonucleoprotein foci related to 5'-to-3' mRNA decay, are dynamically modulated in plant immunity triggered by microbe-associated molecular patterns (MAMPs). The DCP1-DCP2 mRNA decapping complex, a hallmark of P-bodies, positively regulates plant MAMP-triggered responses and immunity against pathogenic bacteria. MAMP-activated MAP kinases directly phosphorylate DCP1 at the serine237 residue, which further stimulates its interaction with XRN4, an exonuclease executing 5'-to-3' degradation of decapped mRNA. Consequently, MAMP treatment potentiates DCP1-dependent mRNA decay on a specific group of MAMP-downregulated genes. Thus, the conserved 5'-to-3' mRNA decay elicited by the MAMP-activated MAP kinase cascade is an integral part of plant immunity. This mechanism ensures a rapid posttranscriptional downregulation of certain immune-related genes that may otherwise negatively impact immunity.

altmetric score

  • 4.5

author list (cited authors)

  • Yu, X., Li, B. o., Jang, G., Jiang, S., Jiang, D., Jang, J., ... He, P.

citation count

  • 12

complete list of authors

  • Yu, Xiao||Li, Bo||Jang, Geng-Jen||Jiang, Shan||Jiang, Daohong||Jang, Jyan-Chyun||Wu, Shu-Hsing||Shan, Libo||He, Ping

publication date

  • August 2019