Three-dimensional coaxial multi-nozzle device for high-rate microsphere generation

abstract

• 2019, Springer Science+Business Media, LLC, part of Springer Nature. To address the need for production of a large number of microspheres for use in various fields such as tissue engineering, we developed a 3D coaxial multi-nozzle flow focusing device fabricated via a simple 3D printing method that demonstrates a high rate of microsphere production per nozzle. This device has six coaxial microscale nozzles that produce hydrogel microspheres. Two individual partsthe inlet and nozzlecan be made separately by a 3D printer and bonded together using uncured photo-curable resin as glue. The dimensions of the microspheres are between 100 and 1200m. They are produced by adjusting the flow rate ratio between the dispersed and continuous media. A flow rate ratio of 180 demonstrated the highest microsphere production rate of 2.12e+5 microspheres per second (0.25mLmin1). This microsphere production rate per nozzle is four times higher than that of currently available devices.

authors

• Kameoka, Jun

published proceedings

• JOURNAL OF MATERIALS SCIENCE

author list (cited authors)

• Jaligama, S., & Kameoka, J.

citation count

• 4

complete list of authors

• Jaligama, Sravani||Kameoka, Jun

publication date

• November 2019

publisher

• Springer Nature  Publisher

published in

• Journal of Materials Science  Journal

keywords

• 40 Engineering
• 4003 Biomedical Engineering
• Bioengineering

Digital Object Identifier (DOI)

• 10.1007/s10853-019-03865-2

start page

• 14233

end page

• 14242

volume

• 54

issue

• 22

URL

• http://dx.doi.org/10.1007/s10853-019-03865-2