Three-dimensional coaxial multi-nozzle device for high-rate microsphere generation Academic Article uri icon


  • 2019, Springer Science+Business Media, LLC, part of Springer Nature. To address the need for production of a large number of microspheres for use in various fields such as tissue engineering, we developed a 3D coaxial multi-nozzle flow focusing device fabricated via a simple 3D printing method that demonstrates a high rate of microsphere production per nozzle. This device has six coaxial microscale nozzles that produce hydrogel microspheres. Two individual partsthe inlet and nozzlecan be made separately by a 3D printer and bonded together using uncured photo-curable resin as glue. The dimensions of the microspheres are between 100 and 1200m. They are produced by adjusting the flow rate ratio between the dispersed and continuous media. A flow rate ratio of 180 demonstrated the highest microsphere production rate of 2.12e+5 microspheres per second (0.25mLmin1). This microsphere production rate per nozzle is four times higher than that of currently available devices.

published proceedings


author list (cited authors)

  • Jaligama, S., & Kameoka, J.

citation count

  • 4

complete list of authors

  • Jaligama, Sravani||Kameoka, Jun

publication date

  • November 2019