Redox regulation of c-Ha-ras and osteopontin signaling in vascular smooth muscle cells: implications in chemical atherogenesis. Academic Article

abstract

• Reduction/oxidation (redox) reactions play a central role in the regulation of vascular cell functions. Recent studies in this laboratory have identified c-Ha-ras and osteopontin genes as critical molecular targets during oxidant-induced atherogenesis. This review focuses on the deregulation of gene transcription by redox-activated trans-acting factors after benzo(a)pyrene challenge and the modulation of extracellular matrix signaling in vascular smooth muscle cells by allylamine-induced oxidative injury. The induction of atherogenic vascular smooth muscle cell phenotypes by chemical injury exhibits remarkable parallels with those seen in other forms of atherogenesis.

authors

• Ramos, Kenneth

published proceedings

• Annu Rev Pharmacol Toxicol

author list (cited authors)

• Ramos, K. S.

citation count

• 41

complete list of authors

• Ramos, KS

publication date

• April 1999

publisher

• Annual Reviews  Publisher

published in

• Annual Review of Pharmacology and Toxicology  Journal

keywords

• Animals
• Arteriosclerosis
• Base Sequence
• DNA Adducts
• Environmental Pollutants
• Genes, Ras
• Humans
• Molecular Sequence Data
• Muscle, Smooth, Vascular
• Osteopontin
• Oxidants
• Oxidation-Reduction
• Sialoglycoproteins
• Signal Transduction

PubMed Central ID

• 10331084

Digital Object Identifier (DOI)

• 10.1146/annurev.pharmtox.39.1.243

start page

• 243

end page

• 265

volume

• 39

issue

• 1