Variants of phosphotriesterase for the hydrolysis and detoxification of nerve agents Patent uri icon

abstract

  • Variants of phosphotriesterase have been created that exhibit enhanced hydrolysis of V-type and G-type nerve agents over wild-type phosphotriesterase. V- and G-type nerve agents have an SP and RP enantiomer. The SP enantiomers are more toxic. V-type nerve agents are among the most toxic substances known. Variants of phosphotriesterase can prefer to hydrolyze one enantiomer of VX over the other enantiomer.

author list (cited authors)

  • Raushel, F. M., & Bigley, A. N.

complete list of authors

  • Raushel, Frank M||Bigley, Andrew N

publication date

  • May 2019