Compositions and methods of enhancing immune responses Patent uri icon


  • Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.

author list (cited authors)

  • Bottje, W., Hargis, B., Berghman, L., Kwon, Y. M., Cole, K., Cox, M., & Layton, S.

complete list of authors

  • Bottje, Walter||Hargis, Billy||Berghman, Luc||Kwon, Young Min||Cole, Kimberly||Cox, Mandy||Layton, Sherryll

publication date

  • June 2018