Conjugation of Dasatinib with MHI‐148 Has a Significant Advantageous Effect in Viability Assays for Glioblastoma Cells Academic Article uri icon

abstract

  • We hypothesized that conjugation of the near-infrared dye MHI-148 with the anti-leukemia drug dasatinib might produce a potential theranostic for glioblastoma. In fact, the conjugate was found to bind the kinases Src and Lyn, and to inhibit the viability of a glioblastoma cell line with significantly greater potency than dasatinib alone, MHI-148 alone, or a mixture of dasatinib and MHI-148 at the same concentration. It was also used to successfully image a subcutaneous glioblastoma tumor in vivo.

altmetric score

  • 1.25

author list (cited authors)

  • Usama, S. M., Jiang, Z., Pflug, K., Sitcheran, R., & Burgess, K.

citation count

  • 4

publication date

  • August 2019

publisher