Towards a systematic framework for the synthesis of operable process intensification systems - application to reactive distillation systems Chapter uri icon


  • 2019 Elsevier B.V. We present a systematic framework for the design and operability/safety optimization of process intensified systems, with specific focus on reactive distillation processes. This framework is based on a phenomenological process intensification/synthesis approach (i.e., Generalized Modular Representation Framework) which first identifies promising intensified tasks and then translates them to equipment-based flowsheet alternatives. Flexibility analysis is integrated with the synthesis model to ensure that resulting design configurations are operable under varying operating conditions. To systematically account for inherent safety performance, risk assessment criteria are included as process constraints involving failure frequency and consequence severity criteria. A case study on the production of methyl tertiary butyl ether is presented to highlight the potential of the proposed approach in deriving inherently operable and safe intensified reactive separation systems.

author list (cited authors)

  • Tian, Y., Pappas, I. S., Burnak, B., Katz, J., Avraamidou, S., Diangelakis, N. A., & Pistikopoulos, E. N.

citation count

  • 0

complete list of authors

  • Tian, Yuhe||Pappas, Iosif S||Burnak, Baris||Katz, Justin||Avraamidou, Styliani||Diangelakis, Nikolaos A||Pistikopoulos, Efstratios N

Book Title

  • 29th European Symposium on Computer Aided Process Engineering

publication date

  • January 2019