BMP Signaling in Regulating Mesenchymal Stem Cells in Incisor Homeostasis. Academic Article uri icon


  • Bone morphogenetic protein (BMP) signaling performs multiple essential functions during craniofacial development. In this study, we used the adult mouse incisor as a model to uncover how BMP signaling maintains tissue homeostasis and regulates mesenchymal stem cell (MSC) fate by mediating WNT and FGF signaling. We observed a severe defect in the proximal region of the adult mouse incisor after loss of BMP signaling in the Gli1+ cell lineage, indicating that BMP signaling is required for cell proliferation and odontoblast differentiation. Our study demonstrates that BMP signaling serves as a key regulator that antagonizes WNT and FGF signaling to regulate MSC lineage commitment. In addition, BMP signaling in the Gli1+ cell lineage is also required for the maintenance of quiescent MSCs, suggesting that BMP signaling not only is important for odontoblast differentiation but also plays a crucial role in providing feedback to the MSC population. This study highlights multiple important roles of BMP signaling in regulating tissue homeostasis.

published proceedings

  • J Dent Res

author list (cited authors)

  • Shi, C., Yuan, Y., Guo, Y., Jing, J., Ho, T. V., Han, X., ... Chai, Y.

citation count

  • 16

complete list of authors

  • Shi, C||Yuan, Y||Guo, Y||Jing, J||Ho, TV||Han, X||Li, J||Feng, J||Chai, Y

publication date

  • July 2019