Evaluating hydrogels for implantable probes using SERS Conference Paper uri icon

abstract

  • 2019 SPIE. Now that a fully-implantable, continuous glucose monitor has received FDA approval, optical techniques other than fluorescence will seek to overcome the limited lifetimes resulting from photobleaching. Using plasmonic nanoparticles, we present the potential of reversible SERS-active sensing assays to function as long-term implantable sensors. The assays offer high selectivity and specificity of analyte detection and concentration without loss of emission intensity over time due to photodestruction. These assays are encapsulated in microdomains bounded by polyelectrolyte multilayers (PEMs), permeable to the target but impermeable to proteins. The microdomains are stabilized in hydrogels for biocompatibility and longevity. This study characterizes the performance of pH-sensitive Raman probes in three different hydrogels in a simulated in vivo environment with changing pH over time.

name of conference

  • Plasmonics in Biology and Medicine XVI

published proceedings

  • Progress in Biomedical Optics and Imaging

author list (cited authors)

  • Kotturi, D., Paterson, S., Baldock, V., You, Y., & McShane, M.

citation count

  • 1

complete list of authors

  • Kotturi, Dayle||Paterson, Sureyya||Baldock, Victoria||You, Yil-Hwan||McShane, Mike

editor list (cited editors)

  • Vo-Dinh, T., Ho, H., & Ray, K.

publication date

  • March 2019