Evaluation of Abuse-Deterrent Characteristics of Tablets Prepared via Hot-Melt Extrusion. Academic Article uri icon


  • In this study, the effect of formulation variables and process parameters on the abuse-deterrent (AD)characteristics of a matrix tablet manufactured using hot-melt extrusion (HME) was investigated. The formulation variables included polyethylene oxide (PEO) grades and its input level, while the HME process parameters varied were barrel temperature profile and die diameter. Depending on the diameter of the extrudate (2.5mm or 5.0mm), two different downstream processes were used to prepare the tablets: cryo-milling followed by compression for the 2.5mm extrudate, and cutting followed by compression for the 5.0mm extrudate. A D-optimal statistical design was used to evaluate the impact of formulation and process parameters on various responses, including tablet physical strength, particle size after manipulation, syringeability and injectability, solution viscosity, extractability in solvents, and dissolution rates. It was found that the post-HME extrusion processing method played a critical role in affecting the AD characteristics of abuse-deterrent formulations, likely through changing the tablet compactability and porosity. When the extrudates were cryo-milled-compressed, the tablets could be readily manipulated by milling, which led to high degree of extractability. Under high alcohol concentration, burst drug release was observed for the tablets compressed from cryo-milled extrudates. Additionally, heat exposure during HME process caused significant drop in PEO solution viscosity, likely due to thermal degradation.

published proceedings

  • AAPS PharmSciTech

altmetric score

  • 3.2

author list (cited authors)

  • Xu, X., Siddiqui, A., Srinivasan, C., Mohammad, A., Rahman, Z., Korang-Yeboah, M., ... Ashraf, M.

citation count

  • 14

complete list of authors

  • Xu, Xiaoming||Siddiqui, Akhtar||Srinivasan, Charudharshini||Mohammad, Adil||Rahman, Ziyaur||Korang-Yeboah, Maxwell||Feng, Xin||Khan, Mansoor||Ashraf, Muhammad

publication date

  • June 2019