Comparative uptake of polyamines by prostate and non-prostate cancer cell lines. Academic Article

abstract

• The Km and Vmax of [14C]-radiolabeled polyamines were determined for PC-3 and AT3B-1 cell lines. With PC-3 Km values are in the following order: ornithine> spermidine> spermine> putrescine, while with AT3B-1 it was spermidine> ornithine> spermine> putrescine. To determine which of these polyamines exhibit higher accumulation, the relative uptake of all the four amines was studied with prostate (PC-3, AT3B-1, LNCaP) and non-prostate (MCF-7, KLN-205, OVCAR) cell lines at 10 and 20 microM after 1 hour. Spermine and spermidine accumulated at higher levels in prostate (AT3B-1 and LNCaP) over non-prostate cell lines (p < 0.01). Putrescine accumulated more in PC-3 and LNCaP than the non-prostate cancer cells.

authors

• Palakurthi, Srinath

published proceedings

• Nucl Med Biol

author list (cited authors)

• Srinath, P., McQuarrie, S. A., & Suresh, M. R.

citation count

• 11

complete list of authors

• Srinath, P||McQuarrie, SA||Suresh, MR

publication date

• January 2002

publisher

• Elsevier  Publisher

published in

• Nuclear Medicine and Biology  Journal

keywords

• Animals
• Breast Neoplasms
• Carbon Radioisotopes
• Humans
• Male
• Ornithine
• Polyamines
• Prostatic Neoplasms
• Putrescine
• Radionuclide Imaging
• Rats
• Reproducibility Of Results
• Sensitivity And Specificity
• Spermidine
• Spermine
• Tumor Cells, Cultured
• Urogenital Neoplasms

Digital Object Identifier (DOI)

• 10.1016/s0969-8051(02)00287-1

start page

• 497

end page

• 503

volume

• 29

issue

• 4

URL

• http://dx.doi.org/10.1016/s0969-8051(02)00287-1