Comparative uptake of polyamines by prostate and non-prostate cancer cell lines. Academic Article uri icon


  • The Km and Vmax of [14C]-radiolabeled polyamines were determined for PC-3 and AT3B-1 cell lines. With PC-3 Km values are in the following order: ornithine> spermidine> spermine> putrescine, while with AT3B-1 it was spermidine> ornithine> spermine> putrescine. To determine which of these polyamines exhibit higher accumulation, the relative uptake of all the four amines was studied with prostate (PC-3, AT3B-1, LNCaP) and non-prostate (MCF-7, KLN-205, OVCAR) cell lines at 10 and 20 microM after 1 hour. Spermine and spermidine accumulated at higher levels in prostate (AT3B-1 and LNCaP) over non-prostate cell lines (p < 0.01). Putrescine accumulated more in PC-3 and LNCaP than the non-prostate cancer cells.

published proceedings

  • Nucl Med Biol

author list (cited authors)

  • Srinath, P., McQuarrie, S. A., & Suresh, M. R.

citation count

  • 11

complete list of authors

  • Srinath, P||McQuarrie, SA||Suresh, MR

publication date

  • January 2002