Immunomodulatory ECM-like nanofibrous microspheres for accelerated bone regeneration in diabetes mellitus
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2019 Omnipress - All rights reserved. Statement of Purpose: Bone repair and regeneration process is markedly impaired in diabetes mellitus (DM) that affects hundreds of millions of people worldwide. As a chronic inflammatory disease, DM creates a pro-inflammatory microenvironment in defective sites, leading to delayed bone healing rates and compromised bone repair quality. Current studies on DM-associated bone regeneration, however, adopt the same approaches to normal bone healing and neglect the importance of immuno-modulation in the DM condition, leading to limited bone healing. In this work, we developed a unique bio-inspired osteo-immunomodulatory microspheres that modulates immune cells (macrophages) to create a pro-healing microenvironment for bone regeneration in the DM condition.
