Sustained and prolonged delivery of protein therapeutics using 2d nanosilicates
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© 2019 Omnipress - All rights reserved. Statement of Purpose: We present a nanoengineered system for sustained and prolong delivery of protein therapeutics, which has the potential to impact current orthopedic regeneration strategies. Specifically, we introduce two-dimensional (2D) nanosilicates with high surface area and charged characteristics for delivery of active proteins for more than 30 days. The nanosilicates show high binding efficacy without altering the protein conformation and bioactivity. The released proteins are able to maintain high activity as demonstrated by enhanced differentiation of human mesenchymal stem cells (hMSCs) at 10-fold lower concentration compared to exogenous control. Utilizing the nanosilicates as a delivery vehicle could minimize the negative side effects observed due to use of supraphysiological dosages of protein therapeutics for orthopedic regeneration strategies.
author list (cited authors)
Cross, L. M., Carrow, J. K., Singh, K. A., & Gaharwar, A. K.