Bivalent metal ions modulate human mesenchymal stem cell osteogenic differentiation
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© 2019 Omnipress - All rights reserved. Statement of Purpose: Minerals play vital roles in vivo, working synergistically with vitamins, enzymes, hormones and other nutrient cofactors to regulate the bodys biological functions. Minerals comprise many skeletal and soft tissues as a necessary extracellular matrix building material, and they regulate processes such as heartbeat, blood clotting, internal fluid pressure, nerve response and oxygen transport. However some elements, though present within the human body, have effects that are not well understood. The role of elements Strontium (Sr) and Zinc (Zn) has not been well characterized in the osteochondral interface. Sr2+ is an alkaline earth metal similar in molecular weight and charge to calcium (Ca2+), and may have a role in osteogenesis due to this similarity. Zn2+ is shown to increase ATPase activity, and regulates transcription of osteoblastic differentiation genes, such as collagen (type I), alkaline phosphatase (ALP), osteopontin, and osteocalcin. Despite these studies, the effect of these minerals on human mesenchymal stem cell (hMSC) differentiation is not thoroughly investigated. In this study, we will investigate the effect of these minerals on hMSC viability and differentiation.
author list (cited authors)
Brokesh, A., Kersey, A., Cross, L., & Gaharwar, A. K.