Biodegradable shape memory polymer (Smp) semi-interpenetrating networks (semi-ipns) with highly tunable properties for bone regeneration
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2019 Omnipress - All rights reserved. Statement of Purpose: We have proposed poly(-caprolactone)-diacrylate (PCL-DA) shape memory polymer (SMP) scaffolds as a potential tissue engineering (TE) strategy to better treat craniomaxillofacial (CMF) bone defects. Current treatment options are limited by the difficulty in fitting rigid bone grafts into defects with complex geometries resulting in poor osseointegration. The SMP scaffolds become malleable with mere exposure to warm saline (T ~55C) and can be easily press-fitted into irregular-shaped CMF bone defects. PCL-DA scaffolds were shown to have high shape fixity/recovery, robust (non-brittle) mechanical properties, and highly interconnected pores;1 however, PCL is known to degrade relatively slow in vivo (~1-2 years), compared to bone neotissue formation (~3-12 weeks). More recently, thermoplastic poly(L-lactic acid) (PLLA) of a single molecular weight (Mn ~15 kDa) was incorporated into the PCL-DA network to produce a semi-interpenetrating network (semi-IPN). Semi-IPNs exhibited accelerated degradation with increasing PLLA content.2 To better understand this behavior and to achieve further control over scaffold degradation rates and mechanical properties, this work explores the impact of PLLA thermoplastic Mn, and thermoplastic polymer composition.
