Silicon-containing shape memory polymer (Smp) scaffolds for cranial bone defect repair
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© 2019 Omnipress - All rights reserved. Statement of Purpose: Cranial bone defects may result from trauma, tumor removal or congenital disease. Autografts, the gold standard, are limited by donor site morbidity and graft resorption which results from the inability to conformally fit the rigid graft into the defect. To address this limitation, we have previously reported thermoresponsive shape memory polymer (SMP) scaffolds that are able to be press-fitted into an irregular defect upon the mere the application of warm saline where upon it would return to its more rigid state once cooled to body temperature.1 These biodegradable SMP scaffolds were based on crosslinked poly(ε-caprolactone) diacrylate (PCL-DA) networks.1 Photocure of PCL-DA around a fused salt template produced scaffolds with highly interconnected pores. Additionally, towards tuning degradation behavior, the PCL-DA macromer was modified by inclusion of polydimethylsiloxane (PDMS) to form a triblock macromer (AcO-PCLn-block-PDMSm-block-PCLn-OAc) then cured to form a PDMS-PCL network.2 Due to its low Tg, PDMS served as an effective softening segment to the overall network and produced networks with excellent shape fixity and shape recovery. Herein, further investigation of PCL:PDMS networks was conducted by including PDMS as a co-monomer network, wherein PDMS was not constricted as a block repeating unit. Furthermore, PDMS of linear and star architectures with various PCL to PDMS weight percentages were investigated to determine the impact of composition on porosity, shape memory behavior, mechanical properties, bioactivity and degradation.
author list (cited authors)
Beltran, F. O., Houk, C. J., & Grunlan, M. A.