Antimicrobial potential of bismuth lipophilic nanoparticles embedded into chitosan-based membrane.
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The objective of this work was to analyze the antimicrobial and antibiofilm activities of bismuth lipophilic nanoparticles (BisBAL NPs) incorporated into chitosan-based membranes. Chitosan-based membranes were homogeneously embedded with BisBAL NPs, confirming the bismuth presence by scanning electron microscopy. The tensile strength of chitosan-based membrane alone or with BisBAL NPs showed similar results as elongation, suggesting that BisBAL NP addition did not affect membrane mechanical properties. Chitosan-based membranes complemented with 100 M of BisBAL NPs caused a complete inhibition of biofilm formation and a 90-98% growth inhibition of six different oral pathogens. Cytotoxicity studies revealed that 80% of human gingival fibroblasts were viable after a 24-h exposure to the chitosan-based membrane with 100 M of BisBAL NPs and collagen. Altogether, we conclude that the biological properties of chitosan-based membranes supplemented with BisBAL NPs could be a very interesting option for tissue regeneration.
author list (cited authors)
Martnez-Martnez, M. A., Hernandez-Delgadillo, R., Abada, B. S., Pineda-Aguilar, N., Sols-Soto, J. M., Nakagoshi-Cepeda, M., ... Cabral-Romero, C.
complete list of authors
Martínez-Martínez, Marco Antonio||Hernandez-Delgadillo, Rene||Abada, Bilal Saad||Pineda-Aguilar, Nayely||Solís-Soto, Juan Manuel||Nakagoshi-Cepeda, María Argelia Akemi||Nakagoshi-Cepeda, Sergio Eduardo||Chellam, Shankararaman||Sánchez-Nájera, Rosa Isela||Cabral-Romero, Claudio