The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Academic Article uri icon

abstract

  • Alcoholic liver disease (ALD) progresses from a normal liver, to steatosis, steatohepatitis, fibrosis and hepatocellular carcinoma (HCC). Despite intensive studies, the pathogenesis of ALD is poorly understood, in part due to a lack of suitable animal models which mimic the stages of ALD progression. Furthermore, the role of IL-17 in ALD has not been evaluated. We and others have recently demonstrated that IL-17 signaling plays a critical role in development of liver fibrosis and cancer. Here we summarize the most recent evidence supporting the role of IL-17 in ALD. As a result of a collaborative effort of Drs. Karin, Gao, Tsukamoto and Kisseleva, we developed several improved models of ALD in mice: 1) chronic-plus-binge model that mimics early stages of steatohepatitis, 2) intragastric ethanol feeding model that mimics alcoholic steatohepatitis and fibrosis, and 3) diethylnitrosamine (DEN)+alcohol model that mimics alcoholic liver cancer. These models might provide new insights into the mechanism of IL-17 signaling in ALD and help identify novel therapeutic targets.

published proceedings

  • Curr Pathobiol Rep

altmetric score

  • 0.5

author list (cited authors)

  • Ma, H., Xu, J., Liu, X., Zhu, Y., Gao, B., Karin, M., ... Kisseleva, T

citation count

  • 21

complete list of authors

  • Ma, Hsiao-Yen||Xu, Jun||Liu, Xiao||Zhu, Yunheng||Gao, Bin||Karin, Michael||Tsukamoto, Hidekazu||Jeste, Dilip V||Grant, Igor||Roberts, Amanda J||Contet, Candice||Geoffroy, Cedric||Zheng, Binhai||Brenner, David||Kisseleva, Tatiana

publication date

  • March 2016