Synthesis of Operable Process Intensification Systems-Steady-State Design with Safety and Operability Considerations Academic Article uri icon


  • Copyright 2018 American Chemical Society. In this work, we present an integrated approach to synthesize process intensification systems with guaranteed flexibility and safety performances. The synthesis of intensified equipment/flowsheets is addressed through the Generalized Modular Representation Framework (GMF), which utilizes an aggregation of multifunctional mass/heat exchange modules to represent chemical processes. Thus, the optimal design options are investigated as mass- and heat-transfer opportunities using superstructure-based optimization techniques without a prepostulation of plausible configurations. To ensure that the designs can be operated under a specified range of uncertain parameters, a multiperiod GMF representation is developed based on the critical operating conditions identified by flexibility test. Risk assessment, accounting for equipment failure frequency and consequence severity, is incorporated as a constraint into this synthesis model to derive inherently safer designs. The resulting safely operable intensified systems, which are represented via phenomenological modules, are then identified as corresponding equipment-based flowsheets and validated with steady-state simulation. We demonstrate the proposed approach through a case study for the production of methyl tert-butyl ether. The results indicate that safety and operability considerations can result in significant changes in the structural and operating parameters of the optimal intensified design configuration.

published proceedings


altmetric score

  • 1.1

author list (cited authors)

  • Tian, Y., & Pistikopoulos, E. N.

citation count

  • 35

complete list of authors

  • Tian, Yuhe||Pistikopoulos, Efstratios N

publication date

  • April 2019