DEAH-RHA helicaseZnf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes. Academic Article

abstract

• Multi-zinc finger proteins are an emerging class of cofactors in DEAH-RHA RNA helicases across highly divergent eukaryotic lineages. DEAH-RHA helicasezinc finger cofactor partnerships predate the split of kinetoplastid protozoa, which include several human pathogens, from other eukaryotic lineages 100-400 Ma. Despite a long evolutionary history, the prototypical DEAH-RHA domains remain highly conserved. This short review focuses on a recently identified DEAH-RHA helicasezinc finger cofactor system in kinetoplastid RNA editing, and its potential functional parallels with analogous systems in embryogenesis control in nematodes and antivirus protection in humans.

authors

• Cruz-Reyes, Jorge

published proceedings

• RNA Dis

author list (cited authors)

• Cruz-Reyes, J., Mooers, B., Abu-Adas, Z., Kumar, V., & Gulati, S.

citation count

• 6

complete list of authors

• Cruz-Reyes, Jorge||Mooers, Blaine HM||Abu-Adas, Zakaria||Kumar, Vikas||Gulati, Shelly

publication date

• January 2016

publisher

• Smart Science and Technology, LLC  Publisher

published in

• http://www.smartscitech.com/index.php/RD  Journal

keywords

• Antivirus Zap
• Deah-rha Rna Helicase
• Dxh30
• H2f1
• Kinetoplastid Rna Editing
• Mog Helicase
• Mop-i
• Reh2
• Trypanosoma Brucei Mitochondria
• Zinc Finger Protein Cofactor

PubMed Central ID

• 27540585

Digital Object Identifier (DOI)

• 10.14800/rd.1336

start page

• e1336

volume

• 3

issue

• 2

URL

• http://dx.doi.org/10.14800/rd.1336