DEAH-RHA helicaseZnf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes. Academic Article uri icon

abstract

  • Multi-zinc finger proteins are an emerging class of cofactors in DEAH-RHA RNA helicases across highly divergent eukaryotic lineages. DEAH-RHA helicasezinc finger cofactor partnerships predate the split of kinetoplastid protozoa, which include several human pathogens, from other eukaryotic lineages 100-400 Ma. Despite a long evolutionary history, the prototypical DEAH-RHA domains remain highly conserved. This short review focuses on a recently identified DEAH-RHA helicasezinc finger cofactor system in kinetoplastid RNA editing, and its potential functional parallels with analogous systems in embryogenesis control in nematodes and antivirus protection in humans.

published proceedings

  • RNA Dis

author list (cited authors)

  • Cruz-Reyes, J., Mooers, B., Abu-Adas, Z., Kumar, V., & Gulati, S.

citation count

  • 5

publication date

  • January 1, 2016 11:11 AM