DEAH-RHA helicaseZnf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes.
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Multi-zinc finger proteins are an emerging class of cofactors in DEAH-RHA RNA helicases across highly divergent eukaryotic lineages. DEAH-RHA helicasezinc finger cofactor partnerships predate the split of kinetoplastid protozoa, which include several human pathogens, from other eukaryotic lineages 100-400 Ma. Despite a long evolutionary history, the prototypical DEAH-RHA domains remain highly conserved. This short review focuses on a recently identified DEAH-RHA helicasezinc finger cofactor system in kinetoplastid RNA editing, and its potential functional parallels with analogous systems in embryogenesis control in nematodes and antivirus protection in humans.
author list (cited authors)
Cruz-Reyes, J., Mooers, B., Abu-Adas, Z., Kumar, V., & Gulati, S.