Flavin-N5-oxide intermediates in dibenzothiophene, uracil, and hexachlorobenzene catabolism. Chapter

abstract

• Flavin-N5-oxide is a new intermediate in flavoenzymology. Here we describe the identification of DszA (dibenzothiophene catabolism), RutA (uracil catabolism) and HcbA1 (hexachlorobenzene catabolism) as flavin-N5-oxide-utilizing enzymes. Mechanistic analysis of these reactions suggests a model for the identification of other examples of this catalytic motif.

authors

• Begley, Tadhg

author list (cited authors)

• Adak, S., & Begley, T. P.

citation count

• 5

complete list of authors

• Adak, Sanjoy||Begley, Tadhg P

Book Title

• NEW APPROACHES FOR FLAVIN CATALYSIS

publication date

• January 2019

publisher

• Elsevier  Publisher

published in

• METHODS IN ENZYMOLOGY  Journal

keywords

• Bacterial Proteins
• Biocatalysis
• Dibenzothiophene Catabolism
• Dsza
• Enzyme Assays
• Escherichia Coli
• Flavin-n5-oxide Detection
• Flavins
• Hcba1
• Hexachlorobenzene
• Hexachlorobenzene Catabolism
• Mechanism
• Oxygenases
• Predicted Use
• Rhodococcus
• Ruta
• Thiophenes
• Uracil
• Uracil Catabolism

PubMed Central ID

• 31072497

Digital Object Identifier (DOI)

• 10.1016/bs.mie.2019.03.020

International Standard Book Number (ISBN) 13

• 9780128168295

start page

• 455

end page

• 468

volume

• 620

URL

• http://dx.doi.org/10.1016/bs.mie.2019.03.020