Multifunctional analytical platform on a paper strip: separation, preconcentration, and subattomolar detection. Academic Article

abstract

• We report a plasmonic paper-based analytical platform with functional versatility and subattomolar (<10(-18) M) detection limit using surface-enhanced Raman scattering as a transduction method. The microfluidic paper-based analytical device (PAD) is made with a lithography-free process by a simple cut and drop method. Complex samples are separated by a surface chemical gradient created by differential polyelectrolyte coating of the paper. The PAD with a starlike shape is designed to enable liquid handling by lateral flow without microchannel patterning. This design generates a rapid capillary-driven flow capable of dragging liquid samples as well as gold nanorods into a single cellulose microfiber, thereby providing an extremely preconcentrated and optically active detection spot.

authors

• Tian, Limei

published proceedings

• Anal Chem

author list (cited authors)

• Abbas, A., Brimer, A., Slocik, J. M., Tian, L., Naik, R. R., & Singamaneni, S.

citation count

• 143

publication date

• January 2013

publisher

• American Chemical Society (ACS)  Publisher

published in

• Analytical Chemistry  Journal

keywords

• Carotenoids
• Chemical Fractionation
• Chlorophyll
• Fluorescent Dyes
• Gold
• Microfluidic Analytical Techniques
• Microscopy, Electron, Transmission
• Nanotubes
• Paper
• Plant Extracts
• Polyamines
• Polymers
• Spectrometry, Fluorescence
• Spectrum Analysis, Raman
• Spinacia Oleracea
• Sulfonic Acids

Digital Object Identifier (DOI)

• 10.1021/ac303567g

start page

• 3977

end page

• 3983

volume

• 85

issue

• 8

URL

• http://dx.doi.org/10.1021/ac303567g