Family history of prostate cancer and age-related trend of testosterone levels among US males: NHANES 2003-2004.
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BACKGROUND: Studies have suggested that rapid age-related declines of testosterone (T) level may play a critical role in the development of prostate cancer (PCa), and family history of PCa is another well-established risk factor of PCa, which have been reported to be associated with androgen metabolism-related genes. However, few studies have ever investigated whether a family history of PCa influences the risk of PCa via regulating the age-related trend of T level among males over the life course. OBJECTIVES: To examine the association between family history of PCa and age-related trend of T levels. MATERIALS AND METHODS: We used National Health and Nutrition Examination Survey (NHANES) data from 2003 to 2004 (n = 322) to compare the age-specific T levels in males with a family history of PCa and those without. RESULTS: We found that between two younger age groups (ages 20-39 and 40-59), there was a more pronounced drop-off in T levels among men with a family history of PCa compared to men without a family history. DISCUSSION AND CONCLUSION: This preliminary analysis suggested that men with a family history of PCa may experience a sharper decline in T level over the life course as compared to males without a family history. However, no conclusions can be made due to small sample sizes. Further longitudinal studies with large sample sizes are needed.
author list (cited authors)
Zhang, X., Zhong, Y., Taylor, N., & Xu, X
complete list of authors
Zhang, X||Zhong, Y||Taylor, N||Xu, X