One Basic Blueprint, Many Different Motors. Academic Article uri icon


  • The cytoplasmic C ring of the bacterial flagellum is known as the switch complex. It binds the response regulator phospho-CheY to control the direction of flagellar rotation. The C ring of enteric bacteria is well characterized. However, no Gram-positive switch complex had been modeled. Ward et al. (E. Ward, E. A. Kim, J. Panushka, T. Botelho, et al., J Bacteriol 201:e00626-18, 2019, propose a structure for the Bacillus subtilis switch complex based on extensive biochemical studies. The work demonstrates that a similar architecture can accommodate different proteins and a reversed signaling logic.

published proceedings

  • J Bacteriol

author list (cited authors)

  • Manson, M. D.

complete list of authors

  • Manson, Michael D

editor list (cited editors)

  • Stock, A. M.

publication date

  • January 1, 2019 11:11 AM