On-line reaction monitoring and mechanistic studies by mass spectrometry: Negishi cross-coupling, hydrogenolysis, and reductive amination.
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Reaction monitoring using inductive ESI mass spectrometry allows chemical reactions to be tracked in real time, including air- and moisture-sensitive as well as heterogeneous reactions. Highly concentrated solutions can also be monitored for long periods without emitter clogging. Sheath gas assists in nebulization and a sample splitter reduces the delay time and minimizes contamination of the instrument. Short-lived intermediates (ca.5s) were observed in Pd/C-catalyzed hydrogenolysis, and several intermediates were seen in Negishi cross-coupling reactions.
author list (cited authors)
Yan, X., Sokol, E., Li, X., Li, G., Xu, S., & Cooks, R. G.
complete list of authors
Yan, Xin||Sokol, Ewa||Li, Xin||Li, Guangtao||Xu, Shiqing||Cooks, R Graham