On-line reaction monitoring and mechanistic studies by mass spectrometry: Negishi cross-coupling, hydrogenolysis, and reductive amination. Academic Article uri icon


  • Reaction monitoring using inductive ESI mass spectrometry allows chemical reactions to be tracked in real time, including air- and moisture-sensitive as well as heterogeneous reactions. Highly concentrated solutions can also be monitored for long periods without emitter clogging. Sheath gas assists in nebulization and a sample splitter reduces the delay time and minimizes contamination of the instrument. Short-lived intermediates (ca.5s) were observed in Pd/C-catalyzed hydrogenolysis, and several intermediates were seen in Negishi cross-coupling reactions.

published proceedings

  • Angew Chem Int Ed Engl

altmetric score

  • 4.75

author list (cited authors)

  • Yan, X., Sokol, E., Li, X., Li, G., Xu, S., & Cooks, R. G.

citation count

  • 82

complete list of authors

  • Yan, Xin||Sokol, Ewa||Li, Xin||Li, Guangtao||Xu, Shiqing||Cooks, R Graham

publication date

  • January 2014