On-line reaction monitoring and mechanistic studies by mass spectrometry: Negishi cross-coupling, hydrogenolysis, and reductive amination. Academic Article

abstract

• Reaction monitoring using inductive ESI mass spectrometry allows chemical reactions to be tracked in real time, including air- and moisture-sensitive as well as heterogeneous reactions. Highly concentrated solutions can also be monitored for long periods without emitter clogging. Sheath gas assists in nebulization and a sample splitter reduces the delay time and minimizes contamination of the instrument. Short-lived intermediates (ca.5s) were observed in Pd/C-catalyzed hydrogenolysis, and several intermediates were seen in Negishi cross-coupling reactions.

authors

• Xu, Shiqing
• Yan, Xin

published proceedings

• Angew Chem Int Ed Engl

altmetric score

• 4.75

author list (cited authors)

• Yan, X., Sokol, E., Li, X., Li, G., Xu, S., & Cooks, R. G.

citation count

• 82

complete list of authors

• Yan, Xin||Sokol, Ewa||Li, Xin||Li, Guangtao||Xu, Shiqing||Cooks, R Graham

publication date

• January 2014

publisher

• Wiley  Publisher

published in

• Angewandte Chemie International Edition  Journal

keywords

• Air-/moisture-sensitive Reactions
• Amination
• Catalysis
• Cross-coupling
• Mass Spectrometry
• Palladium
• Reaction Intermediates
• Reaction Kinetics

Digital Object Identifier (DOI)

• 10.1002/anie.201310493

start page

• 5931

end page

• 5935

volume

• 53

issue

• 23

URL

• http://dx.doi.org/10.1002/anie.201310493