Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis. Academic Article

abstract

• Aminofutalosine synthase (MqnE) catalyzes an important rearrangement reaction in menaquinone biosynthesis by the futalosine pathway. In this Letter, we report the identification of previously unreported inhibitors of MqnE using a mechanism-guided approach. The best inhibitor shows efficient inhibitory activity against H. pylori (IC50 = 1.8 0.4 M) and identifies MqnE as a promising target for antibiotic development.

authors

• Begley, Tadhg

published proceedings

• ACS Med Chem Lett

altmetric score

• 3

author list (cited authors)

• Joshi, S., Fedoseyenko, D., Mahanta, N., Ducati, R. G., Feng, M. u., Schramm, V. L., & Begley, T. P.

citation count

• 15

publication date

• January 2019

publisher

• American Chemical Society (ACS)  Publisher

published in

• ACS Medicinal Chemistry Letters  Journal

keywords

• 5 Development Of Treatments And Therapeutic Interventions
• 5.1 Pharmaceuticals
• Digestive Diseases
• Digestive Diseases - (peptic Ulcer)
• Emerging Infectious Diseases
• Infectious Diseases

Digital Object Identifier (DOI)

• 10.1021/acsmedchemlett.8b00649

start page

• 363

end page

• 366

volume

• 10

issue

• 3

URL

• http://dx.doi.org/10.1021/acsmedchemlett.8b00649