Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis.
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Aminofutalosine synthase (MqnE) catalyzes an important rearrangement reaction in menaquinone biosynthesis by the futalosine pathway. In this Letter, we report the identification of previously unreported inhibitors of MqnE using a mechanism-guided approach. The best inhibitor shows efficient inhibitory activity against H. pylori (IC50 = 1.8 0.4 M) and identifies MqnE as a promising target for antibiotic development.
author list (cited authors)
Joshi, S., Fedoseyenko, D., Mahanta, N., Ducati, R. G., Feng, M. u., Schramm, V. L., & Begley, T. P.