Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis. Academic Article uri icon


  • Aminofutalosine synthase (MqnE) catalyzes an important rearrangement reaction in menaquinone biosynthesis by the futalosine pathway. In this Letter, we report the identification of previously unreported inhibitors of MqnE using a mechanism-guided approach. The best inhibitor shows efficient inhibitory activity against H. pylori (IC50 = 1.8 0.4 M) and identifies MqnE as a promising target for antibiotic development.

published proceedings

  • ACS Med Chem Lett

altmetric score

  • 3

author list (cited authors)

  • Joshi, S., Fedoseyenko, D., Mahanta, N., Ducati, R. G., Feng, M. u., Schramm, V. L., & Begley, T. P.

citation count

  • 15

publication date

  • January 2019