Multifunctional magneto-plasmonic nanotransducers for advanced theranostics: synthesis, modeling and experiment
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© 2015 SPIE. In this work, nano-transducers with a superparamagnetic iron oxide (SPIO) core have been synthesized by preparation of precursor gold nanoseeds loaded on SPIO-embedded silica to form a gold nanoshell. The goal is for such nanotansducers to be used in theranostics to detect brain tumors by using MRI imaging and then assist in their treatment by using photothermal ablation. The iron oxide core provides for the use of a magnetic-field to guide the particles to the target (tumor) site. The gold nanoshell can be then readily heated using incident light and/or an alternating magneticfield. After synthesis of nano-transducer samples, Transmission Electron Microscopy was employed to analyze the formation of each layer. Then UV spectroscopy experiments were conducted to examine the light absorbance of the synthesized samples. The UV-visible absorption spectra shows a clear surface plasmon resonance (SPR) band around 530 nm, verifying the presence of gold coating nanoshells. Finally photothermal experiments using a high-power laser beam with a wavelength of 527 nm were performed to heat the samples. It was found that the temperature reaches 45° C in 12 minutes.
author list (cited authors)
Masoumi, M., Wang, Y. a., Liu, M., Tewolde, M., & Longtin, J.