Discovery of Turn-On Fluorescent Probes for Detecting Bcl-2 Protein. Academic Article uri icon

abstract

  • B-cell-lymphoma-2-gene (Bcl-2) family proteins play a central role in regulating programmed cell death. In cancer, antiapoptotic Bcl-2 proteins, such as Bcl-2 and Mcl-1, are overexpressed. However, there are few developed labeling techniques for tracing the dynamic processes of Bcl-2. To study the physiological process of Bcl-2 protein, a novel series of small-molecule fluorescent probes (1-3) were designed and evaluated for their labeling properties. Our probes can be applied to the identification of tumor-tissue slices and the differentiation of tumor and normal tissues effectively, a feature that renders these probes compatible with future cancer diagnosis in clinical practice.

published proceedings

  • Anal Chem

altmetric score

  • 0.25

author list (cited authors)

  • Liu, T., Dong, G., Xu, F., Han, B. o., Fang, H., Huang, Y., ... Li, M.

citation count

  • 10

complete list of authors

  • Liu, Tingting||Dong, Gaopan||Xu, Feng||Han, Bo||Fang, Hao||Huang, Yun||Zhou, Yubin||Du, Lupei||Li, Minyong

publication date

  • May 2019