Hexachlorobenzene Catabolism Involves a Nucleophilic Aromatic Substitution and Flavin-N5-Oxide Formation. Academic Article

abstract

• HcbA1 is a unique flavoenzyme that catalyzes the first step in the bacterial hexachlorobenzene catabolic pathway. Here we report in vitro reconstitution of the HcbA1-catalyzed reaction. Detailed mechanistic studies provide evidence for nucleophilic aromatic substitution and flavin-N5-oxide formation.

authors

• Begley, Tadhg

published proceedings

• Biochemistry

author list (cited authors)

• Adak, S., & Begley, T. P.

citation count

• 16

complete list of authors

• Adak, Sanjoy||Begley, Tadhg P

publication date

• March 2019

publisher

• American Chemical Society (ACS)  Publisher

published in

• Biochemistry  Journal

keywords

• Catalysis
• Flavins
• Hexachlorobenzene
• Oxygenases

PubMed Central ID

• 30702280

Digital Object Identifier (DOI)

• 10.1021/acs.biochem.9b00012

start page

• 1181

end page

• 1183

volume

• 58

issue

• 9

URL

• http://dx.doi.org/10.1021/acs.biochem.9b00012