Hexachlorobenzene Catabolism Involves a Nucleophilic Aromatic Substitution and Flavin-N5-Oxide Formation. Academic Article uri icon


  • HcbA1 is a unique flavoenzyme that catalyzes the first step in the bacterial hexachlorobenzene catabolic pathway. Here we report in vitro reconstitution of the HcbA1-catalyzed reaction. Detailed mechanistic studies provide evidence for nucleophilic aromatic substitution and flavin-N5-oxide formation.

published proceedings

  • Biochemistry

author list (cited authors)

  • Adak, S., & Begley, T. P.

citation count

  • 16

complete list of authors

  • Adak, Sanjoy||Begley, Tadhg P

publication date

  • March 2019