New insights into the metal-induced oxidative degradation pathways of transthyretin Academic Article uri icon

abstract

  • The amyloidogenic mechanism of transthyretin is still debated but understanding it fully could lend insight into disease progression and potential therapeutics. Transthyretin was investigated revealing a metal-induced (Cr/Cu) oxidation pathway leading to N-terminal backbone fragmentation and oligomer formation; previously hidden details were revealed only by FT-IM-Orbitrap MS and surface-induced dissociation.

author list (cited authors)

  • Poltash, M. L., Shirzadeh, M., McCabe, J. W., Moghadamchargari, Z., Laganowsky, A., & Russell, D. H.

citation count

  • 10

publication date

  • April 2019