New insights into the metal-induced oxidative degradation pathways of transthyretin. Academic Article

abstract

• The amyloidogenic mechanism of transthyretin is still debated but understanding it fully could lend insight into disease progression and potential therapeutics. Transthyretin was investigated revealing a metal-induced (Cr/Cu) oxidation pathway leading to N-terminal backbone fragmentation and oligomer formation; previously hidden details were revealed only by FT-IM-Orbitrap MS and surface-induced dissociation.

authors

• Laganowsky, Arthur
• Russell, David

published proceedings

• Chem Commun (Camb)

author list (cited authors)

• Poltash, M. L., Shirzadeh, M., McCabe, J. W., Moghadamchargari, Z., Laganowsky, A., & Russell, D. H.

citation count

• 17

complete list of authors

• Poltash, Michael L||Shirzadeh, Mehdi||McCabe, Jacob W||Moghadamchargari, Zahra||Laganowsky, Arthur||Russell, David H

publication date

• April 2019

publisher

• Royal Society of Chemistry (RSC)  Publisher

published in

• Chemical Communications  Journal

keywords

• 2 Aetiology
• 2.1 Biological And Endogenous Factors

PubMed Central ID

• 30887985

Digital Object Identifier (DOI)

• 10.1039/c9cc00682f

start page

• 4091

end page

• 4094

volume

• 55

issue

• 28

URL

• http://dx.doi.org/10.1039/c9cc00682f