New insights into the metal-induced oxidative degradation pathways of transthyretin
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The amyloidogenic mechanism of transthyretin is still debated but understanding it fully could lend insight into disease progression and potential therapeutics. Transthyretin was investigated revealing a metal-induced (Cr/Cu) oxidation pathway leading to N-terminal backbone fragmentation and oligomer formation; previously hidden details were revealed only by FT-IM-Orbitrap MS and surface-induced dissociation.
author list (cited authors)
Poltash, M. L., Shirzadeh, M., McCabe, J. W., Moghadamchargari, Z., Laganowsky, A., & Russell, D. H.