Reserpine withdrawal psychosis: the possible role of denervation supersensitivity of receptors. Academic Article

abstract

• A case is reported in which abrupt cessation of long term reserpine therapy for hypertension was followed by hallucinations and mania. Reserpine is thought to induce a denervation sensitivity to dopamine in the basal ganglia and chemotactic trigger zone in man and to catecholaminergic agents in the basal ganglia and mesolimbic system in animals. Conceivably, a parallel supersensitivity in the mesolimbic area could have occurred in this patient and accounted for the psychiatric symptoms. This supersensitivity and the possibility that it may, like tardive dyskinesia, be persistent should be considered when reserpine or similar drugs are used for prolonged periods.

authors

• Kent, Thomas

published proceedings

• J Nerv Ment Dis

author list (cited authors)

• Kent, T. A., & Wilber, R. D.

citation count

• 19

complete list of authors

• Kent, TA||Wilber, RD

publication date

• August 1982

publisher

• Wolters Kluwer  Publisher

published in

• JOURNAL OF NERVOUS AND MENTAL DISEASE  Journal

keywords

• Affective Disorders, Psychotic
• Aged
• Basal Ganglia
• Bipolar Disorder
• Dopamine
• Female
• Hallucinations
• Humans
• Hypertension
• Limbic System
• Receptors, Dopamine
• Reserpine
• Substance Withdrawal Syndrome

PubMed Central ID

• 7097268

Digital Object Identifier (DOI)

• 10.1097/00005053-198208000-00011

start page

• 502

end page

• 504

volume

• 170

issue

• 8