Fast and minimally-invasive tumor margin detection using a novel micromachined “side-viewing” oidrs sensor probe Conference Paper uri icon

abstract

  • © 2010TRF. In this paper, we report the design, fabrication and testing of a novel miniaturized optical sensor probe with “side-viewing” capability. Its unprecedented small size, unique “side-viewing” capability and high optical transmission efficiency enable the agile maneuvering and efficient data collection even in the narrow cavities inside the human body. The sensor probe consists of four micromachined substrates with optical fibers for oblique light incidence and collection of spatially resolved diffuse reflectance from the contacted tissues. The optical sensor probe has been used to conduct the oblique incidence diffuse reflectance spectroscopy (OIDRS) on a human pancreatic specimen. Based on the measurement results, the margin of the malignant tumor has been successfully determined optically, which matches well with the histological results.

author list (cited authors)

  • Chang, C. C., Garcia-Uribe, A., Zou, J., Wang, L. V., Banerjee, B., & Kuczynski, J.

publication date

  • January 2010