A semiparametric efficient estimator in case-control studies for gene-environment independent models. Academic Article

abstract

• Case-controls studies are popular epidemiological designs for detecting gene-environment interactions in the etiology of complex diseases, where the genetic susceptibility and environmental exposures may often be reasonably assumed independent in the source population. Various papers have presented analytical methods exploiting gene-environment independence to achieve better efficiency, all of which require either a rare disease assumption or a distributional assumption on the genetic variables. We relax both assumptions. We construct a semiparametric estimator in case-control studies exploiting gene-environment independence, while the distributions of genetic susceptibility and environmental exposures are both unspecified and the disease rate is assumed unknown and is not required to be close to zero. The resulting estimator is semiparametric efficient and its superiority over prospective logistic regression, the usual analysis in case-control studies, is demonstrated in various numerical illustrations.

authors

• Carroll, Raymond

published proceedings

• J Multivar Anal

author list (cited authors)

• Liang, L., Ma, Y., & Carroll, R. J.

citation count

• 3

complete list of authors

• Liang, Liang||Ma, Yanyuan||Carroll, Raymond J

publication date

• September 2019

publisher

• Elsevier  Publisher

published in

• Journal of Multivariate Analysis  Journal

keywords

• Biased Samples
• Case-control Study
• Gene–environment Independence
• Gene–environment Interaction
• Semiparametric Estimation

PubMed Central ID

• 31680705

Digital Object Identifier (DOI)

• 10.1016/j.jmva.2019.01.006

start page

• 38

end page

• 50

volume

• 173

URL

• http://dx.doi.org/10.1016/j.jmva.2019.01.006