Myelin-associated inhibitors in axonal growth after CNS injury. Academic Article

abstract

• There are multiple barriers to axonal growth after CNS injury. Myelin-associated inhibitors represent one group of barriers extrinsic to the injured neurons. Nogo, MAG and OMgp are three prototypical myelin inhibitors that signal through multiple neuronal receptors to exert growth inhibition. Targeting myelin inhibition alone modulates the compensatory sprouting of uninjured axons but the effect on the regeneration of injured axons is limited. Meanwhile, modulating sprouting, a naturally occurring repair mechanism, may be a more attainable therapeutic goal for promoting functional repair after CNS injury in the near term.

authors

• Geoffroy, Cedric

published proceedings

• Curr Opin Neurobiol

altmetric score

• 1

author list (cited authors)

• Geoffroy, C. G., & Zheng, B.

citation count

• 135

complete list of authors

• Geoffroy, Cédric G||Zheng, Binhai

publication date

• January 2014

publisher

• Elsevier  Publisher

published in

• Current Opinion in Neurobiology  Journal

keywords

• Animals
• Axons
• Central Nervous System Diseases
• Humans
• Myelin Proteins
• Myelin Sheath
• Myelin-associated Glycoprotein
• Nerve Regeneration
• Nogo Proteins
• Oligodendrocyte-myelin Glycoprotein

Digital Object Identifier (DOI)

• 10.1016/j.conb.2014.02.012

start page

• 31

end page

• 38

volume

• 27

URL

• http://dx.doi.org/10.1016/j.conb.2014.02.012