Myelin-associated inhibitors in axonal growth after CNS injury. Academic Article uri icon

abstract

  • There are multiple barriers to axonal growth after CNS injury. Myelin-associated inhibitors represent one group of barriers extrinsic to the injured neurons. Nogo, MAG and OMgp are three prototypical myelin inhibitors that signal through multiple neuronal receptors to exert growth inhibition. Targeting myelin inhibition alone modulates the compensatory sprouting of uninjured axons but the effect on the regeneration of injured axons is limited. Meanwhile, modulating sprouting, a naturally occurring repair mechanism, may be a more attainable therapeutic goal for promoting functional repair after CNS injury in the near term.

published proceedings

  • Curr Opin Neurobiol

altmetric score

  • 1

author list (cited authors)

  • Geoffroy, C. G., & Zheng, B

citation count

  • 118

complete list of authors

  • Geoffroy, C├ędric G||Zheng, Binhai

publication date

  • August 2014