The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms.

abstract

• Age is an important consideration for recovery and repair after spinal cord injury. Spinal cord injury is increasingly affecting the middle-aged and aging populations. Despite rapid progress in research to promote axonal regeneration and repair, our understanding of how age can modulate this repair is rather limited. In this review, we discuss the literature supporting the notion of an age-dependent decline in axonal growth after central nervous system (CNS) injury. While both neuron-intrinsic and extrinsic factors are involved in the control of axon growth after injury, here we focus on possible intrinsic mechanisms for this age-dependent decline.

authors

• Geoffroy, Cedric

published proceedings

• Neurosci Lett

altmetric score

• 0.25

author list (cited authors)

• Geoffroy, C. G., Meves, J. M., & Zheng, B.

citation count

• 29

complete list of authors

• Geoffroy, Cédric G||Meves, Jessica M||Zheng, Binhai

publication date

• June 2017

publisher

• Elsevier  Publisher

published in

• NEUROSCIENCE LETTERS  Journal

keywords

• Age Factors
• Aging
• Animals
• Axon Growth
• Axon Regeneration
• Axons
• Cns Injury
• Neuron-intrinsic
• Neurons
• Pyramidal Tracts
• Signal Transduction
• Spinal Cord
• Spinal Cord Injuries
• Spinal Cord Injury
• Spinal Cord Regeneration

Digital Object Identifier (DOI)

• 10.1016/j.neulet.2016.11.003

start page

• 41

end page

• 49

volume

• 652

URL

• http://dx.doi.org/10.1016/j.neulet.2016.11.003