The use of chemogenetic approaches in alcohol use disorder research and treatment.

abstract

• Several novel techniques were developed recently to explore neural circuit mechanisms of neuropsychiatric disorders. These techniques include the Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic tools, which represent valuable platforms for selective and non-invasive control of neural activity with a high degree of spatial resolution. Among all variants, Gq- and Gi-DREADDs are widely used by neuroscientists to dissect out the circuitry and cellular signals. This review is focused on strategies to access a specific neuronal population or circuit using the DREADD technique and summarizes the current knowledge of the DREADDs' application in alcohol use disorder research and therapeutics.

authors

• Wang, Jun

published proceedings

• Alcohol

author list (cited authors)

• Cheng, Y., & Wang, J.

complete list of authors

• Cheng, Yifeng||Wang, Jun

publisher

• Elsevier  Publisher

published in

• ALCOHOL  Journal

keywords

• Alcohol Use Disorder
• Alcoholism
• Animals
• Brain
• Chemogenetic
• Clozapine
• Dreadd
• Humans
• Pharmacogenomic Testing
• Receptors, Muscarinic

PubMed Central ID

• 30442535

Digital Object Identifier (DOI)

• 10.1016/j.alcohol.2018.05.012

start page

• 39

end page

• 45

volume

• 74