Improving the Oxidative Stability of Shape Memory Polyurethanes Containing Tertiary Amines by the Presence of Isocyanurate Triols
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Copyright 2018 American Chemical Society. Shape memory polymers (SMPs) have been proposed for a wide variety of biomedical applications, such as cerebrovascular aneurysm occlusion; however, risks associated with degradation byproduct formation have raised the need for more biostable formulations. In this study, the use of cyclized isocyanates, in the form of isocyanurate-containing alcohols, was examined in aliphatic SMPs as a method of improving biostability. The materials were investigated for thermomechanical behavior, shape memory response, biostability, and cytocompatibility. In vitro experiments indicated that the isocyanurate-containing porous SMPs possess similar mechanical properties, albeit with improved toughness and no impact to strain recovery shape memory behavior, although atmospheric water uptake increased. Importantly, SMP life span was greatly increased, as control materials were demonstrated to fully degrade in accelerated testing by 25 days, while the modified materials retain more than 90% of their original mass. These modifications also resulted in increased cytocompatibility, indicating that this method may be used for translating biomaterials toward clinical applications.
author list (cited authors)
Weems, A. C., Carrow, J. K., Gaharwar, A. K., & Maitland, D. J.