Isolation and characterization of abl gene sequences in Calliphora erythrocephala. Academic Article

abstract

• Screening of genomic DNA libraries with hybridization probes derived from a Drosophila melanogaster c-abl proto-oncogene homologue resulted in the isolation of a set of related sequences from the dipteran Calliphora erythrocephala. Although the region encompassing the c-abl protein kinase domain encodes a polypeptide extremely similar to the Drosophila gene, considerable inter- and intraspecific divergence is found adjacent to this region. Restriction-site heterogeneity and cross-hybridization studies between individual cloned isolates suggest that abl homologues represent a small gene family in the Calliphora genome. As is the case in Drosophila, abl-related transcripts appear to be low in abundance, are synthesized during oogenesis and stored as a maternal mRNA.

authors

• Thomas, Terry

published proceedings

• Gene

altmetric score

• 3

author list (cited authors)

• Durica, D. S., Restrepo, M. A., Thomas, T. L., & Beckingham, K.

citation count

• 12

complete list of authors

• Durica, DS||Restrepo, MA||Thomas, TL||Beckingham, K

publication date

• January 1987

publisher

• Elsevier  Publisher

published in

• Gene  Journal

keywords

• Animals
• Biological Evolution
• Chromosome Mapping
• Cloning, Molecular
• DNA
• Diptera
• Drosophila Melanogaster
• Gene Expression Regulation
• Multigene Family
• Nucleic Acid Hybridization
• Oocytes
• Proto-Oncogenes
• Sequence Homology, Nucleic Acid

Digital Object Identifier (DOI)

• 10.1016/0378-1119(87)90267-8

start page

• 63

end page

• 76

volume

• 59

issue

• 1

URL

• http://dx.doi.org/10.1016/0378-1119(87)90267-8