Isolation and characterization of abl gene sequences in Calliphora erythrocephala.
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Screening of genomic DNA libraries with hybridization probes derived from a Drosophila melanogaster c-abl proto-oncogene homologue resulted in the isolation of a set of related sequences from the dipteran Calliphora erythrocephala. Although the region encompassing the c-abl protein kinase domain encodes a polypeptide extremely similar to the Drosophila gene, considerable inter- and intraspecific divergence is found adjacent to this region. Restriction-site heterogeneity and cross-hybridization studies between individual cloned isolates suggest that abl homologues represent a small gene family in the Calliphora genome. As is the case in Drosophila, abl-related transcripts appear to be low in abundance, are synthesized during oogenesis and stored as a maternal mRNA.
author list (cited authors)
Durica, D. S., Restrepo, M. A., Thomas, T. L., & Beckingham, K.
complete list of authors
Durica, DS||Restrepo, MA||Thomas, TL||Beckingham, K