This paper deals with the design of fixed-structure controllers for two-input two-output (TITO) systems using frequency-domain data. In standard control approaches, a plant model is first derived, then a suitable controller is designed to meet some user-specified performance specifications. Basically, there are two common ways for obtaining mathematical models: white-box modeling and black-box modeling. In both approaches, it is difficult to obtain a simple and accurate model that completely describes the system dynamics. As a result, errors associated with the plant modeling may result in degradation of the desired closed-loop performance. Moreover, the intermediate step of plant modeling introduced for the controller design is a time-consuming task. Hence, the concept of data-based control design is introduced as a possible alternative to model-based approaches. This promising methodology allows us to avoid the under-modeling problem and to significantly reduce the time and workload for the user. Most existing data-based control approaches are developed for single-input single-output (SISO) systems. Nevertheless, a large class of real systems involve several manipulated and output variables. To this end, we attempt here to develop an approach to design controllers for TITO systems using frequency-domain data. In such a method, a set of frequency-domain data is utilized to find an adequate decoupler and to tune a diagonal controller that meets some desired closed-loop performance measures. Two simulation examples are presented to illustrate and demonstrate the efficacy of the proposed method.