The Oral Fluid MEMS/NEMS Chip (OFMNC): diagnostic and translational applications. Academic Article uri icon


  • The ability to monitor health status, disease onset and progression, and treatment outcome through non-invasive means is a most desirable goal in health-care promotion and delivery. There are three prerequisites for this goal to be realized: specific biomarkers associated with a health or disease state, a non-invasive approach to detect and monitor the biomarkers, and the technologies to discriminate between and among the biomarkers. We present a roadmap to achieve these goals using oral fluids as the diagnostic medium to scrutinize the health and/or disease status of individuals. This is an ideal opportunity to bridge state-of-the-art micro-/nano-electromechanical system (MEMS/NEMS) sensors to oral fluid for diagnostic applications. As the "mirror of body", oral fluid is a perfect medium to be explored for health and disease surveillance. The translational applications and opportunities are enormous.

published proceedings

  • Adv Dent Res

altmetric score

  • 3

citation count

  • 50

complete list of authors

  • Li, Y||Denny, P||Ho, C-M||Montemagno, C||Shi, W||Qi, F||Wu, B||Wolinsky, L||Wong, DT

publication date

  • June 2005