Effects of smoking on local delivery of controlled-release doxycycline as compared to scaling and root planing. Academic Article uri icon

abstract

  • This paper examines the effects of smoking on the treatment outcomes of two nonsurgical therapies: (1) scaling and root planing alone (SRP) or (2) controlled-release of subgingivally delivered doxycycline hyclate in a polylactic acid based polymer gel. Subjects from 2 9-month multicenter studies were classified as nonsmokers (never smoked: 100 subjects), former smokers (137 subjects), and current smokers (> or = 10 cigarettes/day: 121 subjects). Clinical parameters were analyzed for treated sites with baseline probing depths > or = 5 mm and for a subset of treated sites with baseline probing depths of > or = 7 mm. Clinical parameters (plaque levels, clinical attachment levels, pocket depths, and bleeding on probing) were analyzed at baseline, 4, 6, and 9 months. In the doxycycline treated group in general, there were neither marked significant differences in clinical attachment gain nor differences in probing depth reduction among the 3 smoking groups. On the other hand, in the scaling and root planing treated group in general, there were significant differences in clinical attachment gain and pocket depth reduction, with non-smokers responding better than former smokers and current smokers at 6 and 9 months. These differences in clinical response between scaling and root planing alone versus controlled-release of locally-delivered doxycycline hyclate among these 3 smoking groups are discussed in relation to treatment implications for smokers.

published proceedings

  • J Clin Periodontol

altmetric score

  • 3

citation count

  • 49

complete list of authors

  • Ryder, MI||Pons, B||Adams, D||Beiswanger, B||Blanco, V||Bogle, G||Donly, K||Hallmon, W||Hancock, EB||Hanes, P||Hawley, C||Johnson, L||Wang, HL||Wolinsky, L||Yukna, R||Polson, A||Carron, G||Garrett, S

publication date

  • October 1999

publisher