Method to produce granulocyte colony stimulating factor from immortalized avian T lymphocytes and method to produce immortalized cells Patent uri icon


  • Immortal avian T lymphocyte cell lines which produce and secrete immune lymphokines are disclosed. These cell lines may be produced from T cells recovered from fowl which have been hyperimmunized in vivo. The activated T cells are first exposed in vitro to a mitogen effective for secondary stimulation thereof, and then virally transformed to produce an immortal cell line. When cultured in vitro, the cell lines produce and secrete immune lymphokines which may be administered to fowl to increase their resistance to infections.

author list (cited authors)

  • Kogut, M., Deloach, J., Stanker, L., Moyes, R., & Hargis, B.

complete list of authors

  • Kogut, Michael||Deloach, John||Stanker, Larry||Moyes, Rita||Hargis, Billy

publication date

  • January 1997