Engineering the production of a conformational variant of occidiofungin that has enhanced inhibitory activity against fungal species Patent uri icon

abstract

  • Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.

author list (cited authors)

  • Smith, J., Ravichandran, A., Lu, S., & Gu, G.

complete list of authors

  • Smith, James||Ravichandran, Akshaya||Lu, Shien||Gu, Ganyu

publication date

  • April 2017