Direct DNA photocleavage by a new intercalating dirhodium(II/II) complex: comparison to Rh2(mu-O2CCH3)4. Academic Article uri icon

abstract

  • Transition metal complexes possessing the intercalating dppz ligand (dppz = dipyrido[3,2-a:2',3'-c]phenazine) typically bind ds-DNA through intercalation (K(b) approximately 10(5)-10(6) M(-1)), and DNA photocleavage by these complexes with visible light proceeds through the generation of a reactive oxygen species. The DNA binding and photocleavage by [Rh(2)(mu-O(2)CCH(3))(2)(eta(1)-O(2)CCH(3))(CH(3)OH)(dppz)](+) (2) is reported and compared to that of Rh(2)(mu-O(2)CCH(3))(4) (1). Spectral changes and an increase in viscosity provide evidence for the intercalation of 2 to double stranded DNA with K(b) = 1.8 x 10(5) M(-1). DNA photocleavage by 2 is observed upon irradiation with lambda(irr) > 395 nm both in air and deoxygenated solution. DNA photocleavage is not observed for 1 or free dppz ligand under these irradiation conditions. The coupling of a single dppz ligand to a dirhodium(II/II) bimetallic core in 2 provides a means to access oxygen-independent DNA photocleavage with visible light.

published proceedings

  • Inorg Chem

altmetric score

  • 3

author list (cited authors)

  • Bradley, P. M., Angeles-Boza, A. M., Dunbar, K. R., & Turro, C.

citation count

  • 72

complete list of authors

  • Bradley, Patricia M||Angeles-Boza, Alfredo M||Dunbar, Kim R||Turro, Claudia

publication date

  • April 2004